Saira Qurban, Hao-Wen Jiang, and Peng-Fei Xu*
https://doi.org/10.1002/chem.202501961
abstract
One of the most difficult issues facing humanity today is thetreatment of cancer. A binary cancer treatment called boronneutron capture therapy (BNCT) works especially well for high-grade gliomas and metastatic brain malignancies. Due to theirpreferential absorption by developing tumor cells, boronatedamino acids have drawn a lot of attention among the severalboron-containing compounds utilized as BNCT agents. In the first section of this review, the fundamental ideas of BNCT arebriefly presented. In the remaining sections, we present a thor-ough analysis and synthesis of several boronated amino acidsusing distinct techniques. This article summarizes the thera-peutic prospects of boron delivery agents and offers a criticalanalysis of them from the perspectives of nuclear medicinedoctors and medicinal chemists.