Ming-Ming Li, Teng-Fei Xiao, Yi-Xiang Geng, Guo-Qiang Xu,* and Peng-Fei Xu*
doi.org/10.1021/acs.orglett.5c02160
ABSTRACT:
Bicyclo[1.1.0]butanes (BCBs), which possess multiple switchable reactive sites, serve as the most direct modular scaffolds for constructing benzene ring bioisosteres. Herein, we describe the precise modulation of BCB reactive sites through Lewis/ Brønsted acid switching to enable the synthesis of challenging spirocycles and bridged frameworks. The divergent reaction outcomes, arising from the precise control of catalysts over the switchable reactive sites of BCBs, are achieved without any substrate modification