Ai-Lian Wang, Huan-Huan Zhao, Hao-Wen Jiang, and Peng-Fei Xu*
https://doi.org/10.1021/acs.orglett.5c01128
In this study, we have devised a strategy that employs oxime carbamate as a bifunctional diamination reagent in combination with SO2 to realize imino-sulfamoylation of alkenes. This protocol is characterized by its mild conditions, operational simplicity, and metal-free nature, while demonstrating broad functional group tolerance for alkenes. Furthermore, the application of this method provides an accessible route to a diverse range of β-amino sulfonamide derivatives.