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258. Chem. Commun., 2023, 59, 2003 - 2006.

date:2023-02-11

Organic photoredox catalyzed dealkylation/acylation of tertiary amines to access amides

Chen Liu,‡  Han-Nan Chen,‡  Teng-Fei Xiao,   Xiu-Qin Hu,*  Peng-Fei Xu and  Guo-Qiang Xu *

https://doi.org/10.1039/D2CC05842A




Abstract

A mild metal-free C–N bond activation strategy for the direct conversion of inert tertiary amines with acyl chlorides into tertiary amides via organic photoredox catalysis is presented. In this protocol, a novel organic photocatalyst (Cz-NI-Ph) that showed excellent catalytic performance during C–N bond cleavage is developed. Moreover, this reaction features green and mild conditions, broad substrate scope, and readily available raw materials.