Organophotoredox catalytic four-component radical-polar crossover cascade reactions for the stereoselective synthesis of β-amido sulfones

Sheng-Qiang Guo,   Hui-Qing Yang,   Yu-Zhen Jiang,   Ai-Lian Wang,   Guo-Qiang Xu,   Yong-Chun Luo,   Zhao-Xu Chen,   Haixue Zheng  and  Peng-Fei Xu  

https://doi.org/10.1039/D2GC00224H

Abstract

Multicomponent diastereoselective synthesis is still very difficult to be achieved in photoredox catalysis. Here we report a green and reliable strategy for the diastereoselective synthesis of β-amido sulfones through the organophotoredox catalytic fourcomponent radical-polar crossover cascade reactions. This transformation features excellent atom-, step-, redox economy and diastereoselectivity. Moreover, DFT calculation studies are performed to provide some insights into the orign of diastereoselectivity.