Huan-Huan Zhao, Xu-Gang Zhang, Hao-Wen Jiang, Yi Zhao, Xiu-Qin Hu,*and Peng-Fei Xu*
https://doi.org/10.1021/acs.orglett.5c03480
ABSTRACT:
Inthisstudy,wedevelopedavisiblelight-mediatedC(sp3)−Haminationstrategyenabledbyligand-to-metalcharge transfer(LMCT)andironcatalysis.TheinexpensiveFe(NO3)3·9H2Oaffordsaphotoactiveironcomplexuponcoordinationwith N-heteroarylsubstrates,andthecomplexundergoesLMCT-inducedβ-homolysistoproduceahigh-valentFe(IV)�Ospecies.The Fe(IV)�Ospeciespromotesalkyl radical formation,enablingefficientC(sp3)−Nbondconstruction.Thereactionoperatesunder mild conditionswithbroad functional group tolerance and excellent scalability, providing a practical platformforC(sp3)−H amination.