Dong-Sheng Ji,* Xin Zhang, Peiqin Zhang, Xiazhen Bao, Yong Yuan, Congde Huo,* and Peng-Fei Xu*
https://doi.org/10.1021/acs.orglett.4c04715
Herein, we present a visible-light-induced protocol for the synthesis of highly functionalized oxo-bridged oxocine skeletons. This method generates carbenes via visible-light-induced ortho-acyl diazo compounds, which are rapidly intercepted by the oxygen atom of an intermolecular acyl group to form a cyclic 1,3- dipole. The in situ generated highly reactive 1,3-dipole undergoes a facile formal [4 + 3] cycloaddition with alkenyl pyrazolinone, yielding [4.2.1]-oxo-bridged oxocine compounds.