A novel approach for synthesizing α-amino acids via formate mediated hydrogen transfer using a carbon source†

Tian-Tian Zhao,‡a   Xu-Gang Zhang,‡a   Wen-Bo Hea  and  Peng-Fei Xu  *ab  

https://doi.org/10.1039/D3GC02955G

Abstract

Using a formate salt as a promising hydrogen carrier and one-carbon (C1) source, we have developed a novel and practical method for the preparation of α-amino acid derivatives under mild conditions. In this approach, the photoexcited naphthalene thiolate acts simultaneously as a photoexcited single-electron reductant and a hydrogen atom transfer (HAT) catalyst, enabling efficient metal-free radical–radical cross-coupling of formate with ketimines and aldimines.