Shao-Xian Shi, Huan-Huan Zhang, Yi-Lin Wang, Lin-Hong Jiang, Peng-Fei Xu* and Yong-Chun Luo*
https://doi.org/10.1021/acs.orglett.3c01695
Abstract
[2 + 2]-Cycloaddition is the most straightforward approach to the construction of cyclobutanes. In this paper, the intermolecular [2 + 2]-cycloaddition reaction of 3-alkylideneindolin-2-ones with alkenes was achieved. This reaction can be used in the synthesis of 3-spirocyclobutyl oxindoles, polycyclic oxindoles, and late stage modification of some drug molecules.