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260. Org. Lett. 2023, 25, 29, 5426–5430

date:2023-11-21

Visible-Light-Mediated Intermolecular [2 + 2]-Cycloaddition Reaction of 3-Alkylideneindolin-2-one with Alkenes via Triplet Energy Transfer for the Synthesis of 3-Spirocyclobutyl Oxindoles

Shao-Xian Shi, Huan-Huan Zhang, Yi-Lin Wang, Lin-Hong Jiang, Peng-Fei Xu* and Yong-Chun Luo*

https://doi.org/10.1021/acs.orglett.3c01695




Abstract

[2 + 2]-Cycloaddition is the most straightforward approach to the construction of cyclobutanes. In this paper, the intermolecular [2 + 2]-cycloaddition reaction of 3-alkylideneindolin-2-ones with alkenes was achieved. This reaction can be used in the synthesis of 3-spirocyclobutyl oxindoles, polycyclic oxindoles, and late stage modification of some drug molecules.