Kai-Xuan Yang, Dong-Sheng Ji, Haixue Zheng, Yucheng Gu* and Peng-Fei Xu *
https://doi.org/10.1039/D2CC00457G
An inverse-electron-demand oxa-Diels–Alder reaction of 5-alkenyl thiazolones with β,γ-unsaturated carbonyl compounds enabled by quinine thiourea was studied, which allows the enantioselective synthesis of a broad range of highly functionalized pyranthiazoles bearing three continuous stereocenters. This protocol is adaptable to a wide scope of substrates and has great potential for scale-up synthesis and facile transformation.
