Visible-Light-Promoted Multi-step Tandem Reaction of Vinyl Azides toward the Formation of 1-Tetralones

Meng-Jie Jiao, Qiang Hu, Xiu-Qin Hu* and Peng-Fei Xu*

https://doi.org/10.1021/acs.joc.1c02261

ABSTRACT

A visible-light-driven multi-step tandem reaction between vinyl azides and alkyl bromides has been developed leading to the formation of tetralone skeletons under mild conditions, which can be easily scaled up to the gram scale. Various 1-tetralone derivatives are synthesized and transformed into desired products in good to high yields.