Enantioselective Construction of Polycyclic Indazole Skeletons Bearing Five Consecutive Chiral Centers through an Asymmetric Triple-Reaction Sequence

Jia-Lu Zhang, Wen-Long Ye, Jie Zhang, Xiu-Qin Hu,* and Peng-Fei Xu*

DOI: 10.1021/acs.orglett.1c01559

ABSTRACT: A novel approach for the asymmetric construction of polycyclic indazole skeletons via enamine−imine activation and PCET activation was developed by merging organocatalysis with photocatalysis through an asymmetric triple-reaction sequence. In this process, five C−X bonds and five consecutive chiral centers were efficiently constructed. Differently substituted polycyclic indazole deriatives were successfully constructed with satisfactory results under mild conditions.