Ming-Jun Yi,§ Huan-Xin Zhang,§ Teng-Fei Xiao, Ji-Hua Zhang, Zhi-Tao Feng, Li-Pu Wei, Guo-Qiang Xu*, and Peng-Fei Xu*
https://doi.org/10.1021/acscatal.1c00242
Abstruct
Herein, we report a general strategy for the rational design of an efficient organic photocatalyst, and we describe a robust method for the direct C(sp3)–H carbamoylation of saturated aza-heterocycles under mild conditions by using a naphthalimide (NI)-based organic photocatalyst. This protocol provides a concise and practical approach for the rapid installation of a valuable amide bond onto pharmaceutically useful saturated aza-heterocycles to access a wide range of cyclic α-amino amides. A series of mechanism investigations have demonstrated this transformation undergoes a visible-light photocatalytic, oxidative Ugi reaction process.